Blar i forfatter "Hald, Øyvind Holsbø"

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    • Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma 

      Hald, Øyvind Holsbø; Olsen, Lotte; Gallo-Oller, Gabriel; Elfman, Lotta Helena Maria; Løkke, Cecilie; Kogner, Per; Sveinbjørnsson, Baldur; Flægstad, Trond; Johnsen, John Inge; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-12)
      Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...

    • MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN 

      Roth, Sarah Andrea; Hald, Øyvind Holsbø; Fuchs, Steffen; Løkke, Cecilie; Mikkola, Ingvild; Flægstad, Trond; Schulte, Johannes; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)
      Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ...

    • Molecular aspects of high-risk neuroblastoma and novel therapeutic opportunities 

      Hald, Øyvind Holsbø (Doctoral thesis; Doktorgradsavhandling, 2020-05-29)
      Neuroblastoma is a highly heterogenous cancer of childhood. High-risk disease has a poor prognosis with survival around 50% and cured patients suffer treatment related late effects. Better therapy is needed. Increased knowledge of the molecular biology of high-risk neuroblastomas is essential to devise new treatments. High-risk neuroblastomas are frequently MYCN-amplified (MNA). MNA is correlated ...